Elizabeth Copeland is the new chair of the tax section of the State Bar of Texas. She is a tax attorney with Strasburger & Price in San Antonio.
Elizabeth Copeland, a partner in the tax division of Strasburger & Price LLP, has been elected to a leadership position with the State Bar of Texas? tax section. As chair, she will oversee the programming that benefits more than 1,000 tax attorneys in the state.
?We are fortunate to have exemplary lawyers such as Elizabeth in our Tax Practice,? says John Round, chair of Strasburger?s tax practice. ?She demonstrates great dedication to her work, clients and the community.?
Copeland was instrumental in creating the sections? Tax Court Pro Bono Program. In her role as chair, she plans to continue and to expand the work of the program.
Copeland?s area of specialization is civil tax controversies.
Tricia Lynn Silva covers real estate, retail, construction, and law firms; she also plans and edits some special reports.
Apple Inc. said Monday that it is investigating a case in which the family of a 23-year-old woman alleges that she was electrocuted by her iPhone.
Though details about the case remain sketchy, it has caught the imagination of social media users in China, who have been spreading word about the case and warning not to use devices while they are charging.
According to a report in China?s official state-run Xinhua news agency, relatives of the woman in China?s western Xinjiang Uighur Autonomous Region are alleging the woman died after trying to answer a call while her iPhone was charging. An officer with the local Public Security Bureau said Monday that an ?elementary inspection? showed the woman, named Ma Ailun, was electrocuted.
?Her neck had an obvious electronic injury,? he told China Real Time.
Beyond that, though, the official said that the case was still under investigation, and there were no more details available about whether her smartphone, the charger, or something else killed the woman.
In its statement, Apple said: ?We are deeply saddened to learn of this tragic incident and offer our condolences to the Ma family. We will fully investigate and cooperate with authorities in this matter.?
Official media quoted extensively from the microblog feed of a woman who they said was the sister of the victim, though her identity couldn?t be confirmed by China Real Time. She said that her sister had purchased the phone in December. She didn?t indicate whether the phone was Apple?s newest iPhone or an earlier model, and thus far local media reports have had conflicting reports about which model the iPhone might be.
While the fact are still unclear, a number of online users in China focused on the type of charger she might have used. The China Consumers? Association in May warned about the dangers of a ?flood? of uncertified power chargers on the market (in Chinese). In the release the association warned the chargers could turn a smartphone into a ?pocket grenade? and cause explosions, electric shock, or fires in a variety of electronic devices.
?Don?t talk such nonsense, it?s a five volt current, it couldn?t kill a cockroach,? wrote one microblogger. ?What is her house?s surge protector doing??
Another said using a phone while it is plugged in shouldn?t be a problem ?unless you?re using a shoddy transformer. Even if you do that the possibility of this happening is low.?
The case is the most recent in a string of public relations difficulties for Apple in China. In April the Communist Party mouthpiece the People?s Daily put the Cupertino, Calif., company?s app store on a list of websites being investigated for providing pornographic content in China. Earlier that same month, Apple Chief Executive Tim Cook issued an apology to its Chinese customers after the company?s warranty policy came under attack in state media.
? Paul Mozur. Follow him on Twitter @paulmozur
Like China Real Time on Facebook and follow us Twitter for the latest updates.
Source: www.ibtimes.com --- Sunday, July 14, 2013 The man kept his estranged wife in seclusion for nine days leaving nearly 100 cuts on her body with a razor blade. ...
(Reuters) - Despite two failed late-stage trials of its experimental Alzheimer's drug solanezumab, Eli Lilly and Co said on Friday it plans to run yet another study, this time focusing only on mild patients who appeared to respond to the treatment.
And the company will take extra steps to ensure it is testing actual Alzheimer's patients by pre-screening them with its imaging agent Amyvid to ensure they have deposits of the protein beta amyloid that is linked with the disease.
Solanezumab, which patients take by infusion, works by blocking the beta-amyloid protein that forms plaques in the brain signaling the onset of the disease. Bapineuzumab, a similar drug developed by Pfizer Inc, failed its main trial goals last year.
Lilly's two earlier trials of solanezumab had involved patients with mild to moderate symptoms. Combined data from those trials last summer showed the drug slowed cognitive decline by 34 percent in patients who started out with only mild symptoms, but without slowing declines in their ability to perform everyday tasks.
Lilly said the new Phase III trial will consist of 2,100 people, considerably more than the total of about 1,300 with mild Alzheimer's in the earlier two Phase III studies.
"Since Lilly saw a signal of benefit in the mild patients in the completed trials, it makes a lot of sense for them to simply zoom in on that group in this new trial," said Steven Ferris, director of the Alzheimer's Disease Center at NYU Langone Medical Center in New York. "It's a roll of the dice again, but they'll get a definitive answer."
Ferris said Lilly's decision to forge ahead with another trial was a bold move, but one worth taking because no current treatments slow progression of the disease.
"That's what we need."
The Indianapolis company plans to begin enrolling patients in the new study, called Expedition 3, before the end of September, and noted that patients would be treated for 18 months. But Lilly declined to speculate when it will have final data from the high-profile study.
An estimated 5 million Americans have Alzheimer's, the most common cause of dementia. More than 38 million people worldwide are believed to have dementia, including Alzheimer's disease, and those numbers are expected to rise as more people live longer.
WRONG PATIENTS SCREENED
Eric Siemers, senior medical director of Lilly's Alzheimer's program, said an estimated 25 percent of patients in the two earlier Expedition trials might not actually have had beta-amyloid deposits or Alzheimer's disease, so solanezumab could not have helped them.
He said many patients were enrolled in those trials on the basis of symptoms, without undergoing sophisticated diagnostic procedures now available to confirm the presence of beta-amyloid deposits.
In addition to using Amyvid, its new radioactive imaging agent, Siemers said the company will also look at biochemical measures in the spinal fluid can also help assess whether patients have Alzheimer's.
"This pre-screening will take Lilly longer to enroll patients, but is a wise move," Sanford Bernstein analyst Tim Anderson said in a research note. He said the earliest the drug is likely to reach the market, assuming the trial succeeds, is late 2017.
Maria Carrillo, vice president of scientific and medical affairs for the Alzheimer's Association, said the tighter screening will "strengthen" the new study. "When you're using an amyloid-based approach you want to make sure amyloid is there."
Lilly's renewed push behind solanezumab comes amid other recent setbacks for its Alzheimer's program.
Last month Lilly halted a mid-stage study of a different type of Alzheimer's treatment, from a class known as beta secretase, or BACE, inhibitors, after signs of potential liver toxicity. But the company said it remains interested in developing other BACE inhibitors.
Earlier this month, the U.S. Centers for Medicare & Medicaid Services proposed guidelines that would deny reimbursement for Amyvid unless patients are taking part in one of several clinical trials in which the $3,000 test is being used.
In the meantime, two independent studies of solanezumab are just getting off the ground, and could shed further light on the drug's potential.
They involve a study of elderly patients who do not yet have symptoms of Alzheimer's but who have deposits of amyloid in their brains, and a study of patients with an inherited high risk of developing Alzheimer's.
(Reporting by Ransdell Pierson; Editing by Lisa Von Ahn, Julie Steenhuysen and Sofina Mirza-Reid)
WASHINGTON (AP) ? In the courts of law and public opinion, congressional Republicans increasingly accuse President Barack Obama of exceeding his constitutional authority for the benefit of special interests, most recently by delaying a requirement for businesses to provide health care for their workers.
In one instance, Senate Republicans formally backed a lawsuit challenging the president's appointment of three members of the National Labor Relations Board without confirmation. The Supreme Court has agreed to review a ruling in the case, which found that Obama overstepped his bounds.
Most recently, the White House's decision to postpone a key part of the president's health care law drew rhetorical denunciations Tuesday from Republicans who, ironically, want to see the law repealed in its entirety.
Senate Republican leader Mitch McConnell of Kentucky said the action was part of a pattern of "indifference to the rule of law on the part of this administration. ... He did it with immigration. He did it with welfare work requirements. And he did it with the NLRB when he took it upon himself to tell another branch of government when it was in recess.
"And now he's doing it again with his own signature health care law," said McConnell, who is seeking re-election next year in a state where Obama is unpopular.
White House press secretary Jay Carney had no comment on McConnell's complaint that the administration is indifferent to the rule of law. The White House disputes each allegation in turn, citing specific legal authority for the president's actions, or saying the assertion was factually incorrect.
Oddly enough, on one particularly incendiary issue, Obama so far has rejected suggestions that he has authority to continue government borrowing without a vote by Congress to raise the debt ceiling. To switch course would inevitably invite a lawsuit.
Whatever the merits of the Republican claims, they sometimes include a dose of politics of the sort they accuse Obama of playing.
Rep. Steve King, R-Iowa, threatened to sue when Obama announced several weeks before the 2012 election that he would stop deportation proceedings against many younger immigrants who are in the country illegally, so long as they went to college or served in the military. The move was widely viewed as a gesture to Hispanic voters, many of whom live in key battleground states.
A suit subsequently was filed by federal immigration enforcement agents, and King was not a party to it, although his office says it was the product of a meeting he called. King also used the issue to raise money for his own re-election to Congress last fall, emailing potential donors that Obama "refuses to enforce immigration laws."
In addition to challenging Obama's adherence to the rule of law, McConnell's speech included a pre-emptive attack in case Democrats try to change Senate rules this summer and make it easier to confirm presidential appointees.
"I know Washington Democrats are getting a lot of pressure from big labor union bosses and other far-left elements of their base to do this," the Kentucky Republican said. "These folks have told Democrats it's time to pay up, and they don't have much time for things like the democratic process or the rule of law."
He spoke at about the same time House Democrats and union leaders held a news conference to pressure Republicans not to block confirmation for several appointments, including at the NLRB, which rules on collective bargaining disputes between employees and companies.
"Whatever it takes to get these nominees through, an up or down vote is what we want," said Bill Samuel, the AFL-CIO's legislative director. "That might very well include a change in the rules to make it impossible for the Republicans to filibuster the nominations."
The lawsuit backed by Senate Republicans challenged Obama's so-called recess appointments of three members of the NLRB.
The Constitution gives the president authority to make appointments without confirmation when the Senate is in recess. In the case at issue, Obama acted at a time Congress was away on an extended holiday break, but the Senate met every three days as part of an explicit strategy by Republicans to prevent such appointments.
Rejecting the administration's arguments, a three-judge panel of the U.S. Court of Appeals in Washington, D.C., ruled that recess appointments can be made only during the once-a-year break between sessions of Congress, typically at the end of the year.
Two judges on the panel also ruled that to qualify for a recess appointment, a position must become vacant while the Senate is in recess.
Despite Republican allegations, administration officials cite specific legal authority for some of Obama's actions.
The Treasury Department said the one-year waiver of the requirement for companies to provide health insurance announced last week was "an exercise of the administrative authority" granted by law when it comes to implementing new legislation like the health care act.
One official cited other recent examples of waivers under the same authority. A case in 2011 said aviation excise taxes that had lapsed and then been reinstated would not be applied for a three-week period ending the day Congress re-enacted them.
The other, from 2007, related to standards for penalties on income tax preparers, according to the official, who citing department regulations in speaking on condition of anonymity.
A year ago, when Obama announced the shift in immigration policy, Homeland Security Secretary Janet Napolitano cited "prosecutorial discretion."
McConnell's reference to welfare relates to a charge by Republicans that the administration proposed new rules to lessen the work requirements implemented as part of a 1996 overhaul of the program. The White House denies the proposal had that effect.
___
Associated Press writers Jim Kuhnhenn and Sam Hananel contributed to this report.
Microbes that live inside fish intestines are among the array of life that appear to have been found in ice drilled from above Lake Vostok, the deepest lake buried beneath Antarctica's ice sheet.
The ice is thought to be from frozen Vostok lake water, chilled by contact with the lake's overlying glacier. Called accretion ice, scientists first reported evidence of microbes in this ice in the journal Science in 1999. In some spots above the lake, the accretion ice is more than 650 feet (200 meters) thick and 20,000 years old, scientists believe. Though ice has sealed the surface for up to 15 million years, subglacial waterways may have refreshed the lake and even brought in life from outside the basin, scientists think.
Now, a new study of genetic material in the accretion ice reveals more than 3,500 unique traces of life in Lake Vostok, including animals, from a wide variety of ecosystems. Most of the snippets of DNA and RNA are from bacteria and fungi, according to the report, published July 3 in the journal PLOS ONE. Some sequences match living microbes pulled from the same ice cores by the research team in 2008 and 2009, said senior author Scott Rogers, a molecular biologist at Bowling Green State University in Ohio. [Strangest Places Where Life Is Found on Earth]
Although the researchers found genetic evidence of many different organisms in the ice, the overall concentration was incredibly low compared with water from lake systems on other continents, Rogers said, ranging between one cell to 100 cells per milliliter (0.04 ounces) of fluid. "If [Lake Vostok] does have life, it's interesting life, but it's not highly concentrated life," Rogers told LiveScience.
New view of Vostok
Lake Vostok is Antarctica's biggest and deepest subglacial lake; its surface sits 1,600 feet (500 m) below sea level. It is roughly the size of Lake Ontario and lies beneath 2 miles (3.2 kilometers) of ice. The lake basin is about 35 million years old and was entombed after Antarctica underwent a deep freeze about 15 million years ago. Signs of subglacial waterways suggest rivers, streams or floods periodically refresh the lake, so the water in the lake is much younger than 15 million years. However, Rogers estimates the accretion ice tested in the study is between 5,000 to 10,000 years old.
The ice cores analyzed in the current study have been shared and scrutinized internationally since they were extracted in the 1990s by Russian scientists. The first hints of life turned up soon after the cores were removed, such as in the series of papers published in Science in 1999.
In their new study, Rogers and his colleagues discovered genetic sequences from cold-loving extremophiles, adapted to the chilly, light-poor environment. Among the bacteria were species that live in hydrothermal vents and organisms that colonize the intestines of rainbow trout, lobsters and tubeworms.
The team also found stretches of RNA and DNA from animals such as tiny, deep-sea-living mollusks and the water flea, a small floating crustacean found in almost every permanent water body on Earth. "The organisms we've been finding are in the very, very small range. These are tiny little creatures," Rogers said.
Finding Vostok's hotspot
Reports of life from Antarctic lakes, especially from the Vostok ice cores, have been plagued by problems with contamination. In the past decade, Rogers and his team developed a painstaking decontamination technique to remove genetic contagion on the outside of the ice core while preserving the ancient DNA and RNA within, he said. The method involves a bleach wash, as well as melting, filtering and refreezing the ice.
"Contamination is still a concern, but we think the contamination methods we have developed ensure that all the external contamination has been eliminated," Rogers said.
In the future, the team plans to conduct genetic tests on additional ice cores to pin down the center of biological activity above the lake. Studies suggest the shallow part of the lake is the active zone, with the highest cell counts in ice cores from above this region, Rogers said.
"As you get further out into the lake, the cell count really drops," he said. "We're interested in finding out what's there and how they're able to live there. Life seems to find a way to survive almost everywhere on Earth that you can go."
Earlier this year, scientists exploring subglacial Lake Whillans reported the first evidence for microbial life in water retrieved from a buried lake in Antarctica. There are nearly 380 subglacial lakes, remnants of the lost world beneath the ice sheet.
Email Becky Oskin or follow her @beckyoskin. Follow us @livescience, Facebook?& Google+. Original article on LiveScience.com.
Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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When a group of teenagers living in Nazi Germany attempt to flee there country they leave a life of relative safety for a life were danger and death lurk around every corner. Will they make it out alive, or will they fall short to fear or death?
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WASHINGTON (Reuters) - Secretary of State John Kerry's wife, Teresa Heinz Kerry, was rushed to a top Boston hospital from the island of Nantucket, Massachusetts, on Sunday, with an unspecified medical condition.
Glen Johnson, a State Department official who serves as Kerry's personal spokesman, announced her illness but did not give details.
The 74-year-old philanthropist and heiress was in critical but stable condition, a Boston newspaper reported.
"Late Sunday afternoon, Mrs. Teresa Heinz Kerry was taken by ambulance to Nantucket Cottage Hospital, accompanied by her husband," Johnson said in a brief written statement released by the State Department.
"Once doctors had stabilized her condition, she was transferred to Massachusetts General Hospital in Boston, again accompanied by the secretary," he added. "The family is grateful for the outpouring of support it has received and aware of the interest in her condition, but they ask for privacy at this time."
Massachusetts General Hospital is among the United States' top medical centers and is one of the Harvard Medical School's teaching hospitals.
Earlier, a source close to the family said Heinz Kerry's trip to the hospital from the family's summer residence in Nantucket, an island where many wealthy Americans have vacation homes, was necessitated by a "medical condition" rather than an accident.
On its website, the Boston Herald newspaper quoted Cottage Hospital spokesman Noah Brown as saying Heinz Kerry was admitted to the emergency room in critical condition. Her condition has since stabilized, the paper quoted him as saying.
Brown said he had been asked to refer questions to the State Department.
Kerry and his wife have long vacationed on Nantucket, about 30 miles off the south coast of Cape Cod. Many wealthy Americans have summer homes there.
Heinz Kerry was born in the southern African nation of Mozambique and is the widow of Pennsylvania Senator John Heinz III, an heir to the Heinz food fortune.
Heinz, a Republican, died in a helicopter crash in 1991 and she married Kerry, then a Democratic U.S. senator from Massachusetts, in 1995 on Nantucket.
Kerry was one of the richest U.S. senators, mostly due to Heinz Kerry's fortune.
Heinz Kerry is known for being outspoken and famously told a reporter to "shove it" during her husband's unsuccessful presidential bid in 2004.
Kerry's second wife, she is the chairman of the Heinz Endowments and the Heinz Family Philanthropies.
She is active in environmental issues, has served on numerous boards and has been awarded 10 honorary degrees, according to the Heinz Endowment's website.
(Reporting by Arshad Mohammed and Ian Simpson; Editing by Stacey Joyce and Eric Walsh)
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AbleGamers and Minicore Studios, the developer of coming space-dog adventure game Laika Believes, are teaming up to offer grants to purchase assistive gaming technology to players with disabilities. The program is called the "AbleGamers 2013 Summer of Fun Grant Program," and it's open to people of all ages. Take a look at the grant application here.
The application will be live until July 31; after that, the AbleGamers board will review the submissions and dole out funding as they see fit. AbleGamers Founder Mark Barlet says he expects to receive thousands of requests, Game Politics reports.
Minicore Studios founder John Warren says it's an honor to be involved in the grant program.
"Minicore is a huge supporter of the AbleGamers charity," he says. "We love what they do for the gaming community and those with disabilities. This was a perfect opportunity to get involved and help gamers with disabilities play."
According to a document obtained by the Wall Street Journal, Apple will pay 0.13 cents and 15 percent of advertising revenue to major labels for every song played on iTunes Radio in its first year, climbing to .14 cents and 19 percent in year two. In comparison, Pandora currently pays 0.12 cents per song, and WSJ added that Apple is offering publishers more than double Pandora's rate for royalties. There are some exclusions to Apple's offering, however: it won't need to pay for songs streamed for 20 seconds or less, those that are already in your iTunes library or certain promoted tracks. For its part, Pandora said that comparing the two is unfair, since varying features between the services could trigger royalty payments differently. It also addressed recent controversy about those royalties in a detailed blog post (see the More Coverage link below). In addition, insiders say that Apple's primary aim is to encourage listeners to buy more tracks on iTunes, in turn boosting hardware sales. Still, the new service will no doubt reap the benefits of Apples new iAd mobile advertising platform, so it's likely that Cupertino will have its cake and eat it, too.
FRANKFURT (Reuters) - Rolling Stones, known for songs such as "(I Can't Get No) Satisfaction" and "Jumpin' Jack Flash," have won a new publishing deal just as a series of shows this summer is set to boost interest in the band's back catalogue.
BMG, part of German publisher Bertelsmann, has signed to represent the music catalogue of the Stones, who are on tour celebrating 50 years in the music business.
The company gave no value for the deal, in which BMG's responsibilities will range from marketing and licensing songs to the film, TV and advertising sectors, to ensuring the writers are paid promptly and accurately for their use on the fast-growing number of digital music services.
It is the first new publishing deal with an outside company in 40 years for Keith Richards and Mick Jagger, who share writing credits on many of the band's best-known hits.
EMI Music Publishing, which owns the band's songs from 1971-1983, was the last outside company to sign a deal with the band, before the Stones took control over their own compositions.
BMG will from July 1 take direct responsibility for publishing all of the songs written by Jagger and Richards since 1983. Additionally the company will be responsible for handling the pair's shares of their pre-1983 copyrights such as "Angie" and "Brown Sugar".
"This deal is incredibly important for BMG," the company's CEO Hartwig Mausch said in a statement. "Keith and Mick have clearly created one of the most outstanding song collections in rock 'n' roll history".
The Stones, who released their first single, a cover of Chuck Berry's "Come On", in 1963, are gearing up for a gig at British music festival Glastonbury this weekend before playing more dates over the summer in London.
The BMG deal comes on the back of a career-spanning digitally re-mastered back catalogue released on Apple Inc's iTunes Store last week.
(This story has been corrected to add 'known for' in first paragraph to show that BMG did not get the rights for "Satisfaction" and "Jumpin' Jack Flash")
(Reporting by Harro ten Wolde; Editing by David Holmes)
And here we face a conundrum. On the one hand, Sony's Xperia Z Ultra has salivation-worthy guts. On the other hand, the screen on this thing is 6.4 freaking inches! That's not a phone, that's a tablet you talk into.
'Human Evolutionary Genetics' by Jobling, Hollux, Hurles, Kivisild, and Tyler-SmithPublic release date: 26-Jun-2013 [ | E-mail | Share ]
Contact: Alain Mentha alain.mentha@taylorandfrancis.com 917-351-7138 Garland Science, Taylor & Francis Group
New second edition -- now available!
Garland Science is proud to announce the publication of the long-awaited Second Edition of Human Evolutionary Genetics by Jobling, Hollux, Hurles, Kivisild, and Tyler-Smith.
Now in full-color, the Second Edition of Human Evolutionary Genetics has been completely revised to cover the rapid advances in the field since publication of the highly regarded First Edition. Written for upper-level undergraduate and graduate students, it is the only textbook to integrate genetic, archaeological, and linguistic perspectives on human evolution, and to offer a genomic perspective, reflecting the shift from studies of specific regions of the genome towards comprehensive genomewide analyses of human genetic diversity.
Human Evolutionary Genetics is suitable for courses in Genetics, Evolution, and Anthropology. Readers with a background in anthropology will find that the streamlined genetic analysis material contained in the Second Edition is more accessible. The new edition also integrates new technologies (including next-generation sequencing and genomewide SNP typing) and new data analysis methods, including recent data on ancient genomes and their impact on our understanding of human evolution. The book also examines the subject of personal genomics and its implications.
The new Second Edition has been comprehensively revised and updated. New to the Second Edition:
Two new authors contributing additional expertise in genome variation, infectious disease, primatology and anthropology.
Now with a new layout and in full-color throughout, making the text and figures easier to read.
Two additional chapters, reflecting developments in understanding the human genome in the context of other hominid and great ape genomes, and in complex disease.
The guest-authored 'Opinion Boxes' are retained, with completely new boxes and guest authors to reflect current issues and controversies.
Each chapter ends with in-depth review questions.
Comprehensive glossary of over 1,300 terms, doubling the terms in the first edition.
Praise for the First Edition of Human Evolutionary Genetics:
"I strongly recommend this book to anyone with an interest in human evolutionary genetics or anthropological genetics. It would be an ideal choice for advanced undergraduates and graduate courses on this topic, and would also be a key reference for those active in such research." HUMAN GENOMICS
"[Human Evolutionary Genetics] is one of the best textbooks on any subject I have ever read. It belongs on the shelves of everyone interested in the genetic aspects of human evolution. There is also much of value in it for paleoanthropologists, historical linguistics, archaeologists, and human biologists (biological anthropologists), as well as for geneticists with various complementary specialties and interests." AMERICAN JOURNAL OF HUMAN GENETICS
"I strongly recommend Human Evolutionary Genetics as an undergraduate textbook. At the same time, I recommend this book to any readers with an interest in human evolution or human genetics." HUMAN GENETICS
###
About the Book:
Human Evolutionary Genetics, Second Edition (Paperback ISBN: 978-0-8153-4148-2) was written by Mark Jobling, Edward Hollux, Matthew Hurles, Toomas Kivisild, and Chris Tyler-Smith and published by Garland Science. The new edition is available in paperback and is 650 pages with 357 full-color illustrations. Figures in PowerPoint and JPEG formats will be available for instructors.
For additional book information, and to learn about e-book options visit: http://www.garlandscience.com/heg2.
The Authors:
Mark A. Jobling - University of Leicester, UK
Edward Hollox - University of Leicester, UK
Matthew Hurles - Wellcome Trust Sanger Institute, UK
Toomas Kivisild - University of Cambridge, UK
Chris Tyler-Smith - Wellcome Trust Sanger Institute, UK
About Garland Science:
Garland Science has been publishing scientific textbooks of the highest quality for over two decades. In that time, Garland has established itself as one of the leading publishers in the fields of cell and molecular biology, immunology, genetics, and protein sciences. Our publications include such classics as Molecular Biology of the Cell, Essential Cell Biology, Janeway's Immunobiology, The Immune System, The Biology of Cancer, Human Molecular Genetics, and Introduction to Protein Structure.
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'Human Evolutionary Genetics' by Jobling, Hollux, Hurles, Kivisild, and Tyler-SmithPublic release date: 26-Jun-2013 [ | E-mail | Share ]
Contact: Alain Mentha alain.mentha@taylorandfrancis.com 917-351-7138 Garland Science, Taylor & Francis Group
New second edition -- now available!
Garland Science is proud to announce the publication of the long-awaited Second Edition of Human Evolutionary Genetics by Jobling, Hollux, Hurles, Kivisild, and Tyler-Smith.
Now in full-color, the Second Edition of Human Evolutionary Genetics has been completely revised to cover the rapid advances in the field since publication of the highly regarded First Edition. Written for upper-level undergraduate and graduate students, it is the only textbook to integrate genetic, archaeological, and linguistic perspectives on human evolution, and to offer a genomic perspective, reflecting the shift from studies of specific regions of the genome towards comprehensive genomewide analyses of human genetic diversity.
Human Evolutionary Genetics is suitable for courses in Genetics, Evolution, and Anthropology. Readers with a background in anthropology will find that the streamlined genetic analysis material contained in the Second Edition is more accessible. The new edition also integrates new technologies (including next-generation sequencing and genomewide SNP typing) and new data analysis methods, including recent data on ancient genomes and their impact on our understanding of human evolution. The book also examines the subject of personal genomics and its implications.
The new Second Edition has been comprehensively revised and updated. New to the Second Edition:
Two new authors contributing additional expertise in genome variation, infectious disease, primatology and anthropology.
Now with a new layout and in full-color throughout, making the text and figures easier to read.
Two additional chapters, reflecting developments in understanding the human genome in the context of other hominid and great ape genomes, and in complex disease.
The guest-authored 'Opinion Boxes' are retained, with completely new boxes and guest authors to reflect current issues and controversies.
Each chapter ends with in-depth review questions.
Comprehensive glossary of over 1,300 terms, doubling the terms in the first edition.
Praise for the First Edition of Human Evolutionary Genetics:
"I strongly recommend this book to anyone with an interest in human evolutionary genetics or anthropological genetics. It would be an ideal choice for advanced undergraduates and graduate courses on this topic, and would also be a key reference for those active in such research." HUMAN GENOMICS
"[Human Evolutionary Genetics] is one of the best textbooks on any subject I have ever read. It belongs on the shelves of everyone interested in the genetic aspects of human evolution. There is also much of value in it for paleoanthropologists, historical linguistics, archaeologists, and human biologists (biological anthropologists), as well as for geneticists with various complementary specialties and interests." AMERICAN JOURNAL OF HUMAN GENETICS
"I strongly recommend Human Evolutionary Genetics as an undergraduate textbook. At the same time, I recommend this book to any readers with an interest in human evolution or human genetics." HUMAN GENETICS
###
About the Book:
Human Evolutionary Genetics, Second Edition (Paperback ISBN: 978-0-8153-4148-2) was written by Mark Jobling, Edward Hollux, Matthew Hurles, Toomas Kivisild, and Chris Tyler-Smith and published by Garland Science. The new edition is available in paperback and is 650 pages with 357 full-color illustrations. Figures in PowerPoint and JPEG formats will be available for instructors.
For additional book information, and to learn about e-book options visit: http://www.garlandscience.com/heg2.
The Authors:
Mark A. Jobling - University of Leicester, UK
Edward Hollox - University of Leicester, UK
Matthew Hurles - Wellcome Trust Sanger Institute, UK
Toomas Kivisild - University of Cambridge, UK
Chris Tyler-Smith - Wellcome Trust Sanger Institute, UK
About Garland Science:
Garland Science has been publishing scientific textbooks of the highest quality for over two decades. In that time, Garland has established itself as one of the leading publishers in the fields of cell and molecular biology, immunology, genetics, and protein sciences. Our publications include such classics as Molecular Biology of the Cell, Essential Cell Biology, Janeway's Immunobiology, The Immune System, The Biology of Cancer, Human Molecular Genetics, and Introduction to Protein Structure.
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In the event that you own a or youre thinking of operating one, then preparing for its long-term potential might be a large concern of yours. Exactly like any organization, the restaurant industry is packed with challenges and changes that influence of its? lifespan. To ensure its continuing success, a well-thought out plan is definitely a must!
The restaurant business requires a market research before its set-up and throughout its?
Ensuring the achievement of the restaurant industrys long-term potential
If you own a or youre thinking of working one, then planning its long-term future is most likely a large concern of yours. Just like any organization, the restaurant business is packed with problems and changes that affect of its? lifespan. To make certain its continuing success, a well-thought out plan is definitely a must!
The restaurant business requires a market analysis before its set-up and all through its operations in the market. The said market analysis would generally speaking handle various facets in the goal market such as: age; gender; occupation; income; and knowledge amongst others. By distinguishing these facets, the people running the business will have a concept on how to provide their customers and thrive in competition with other restaurants catering to exactly the same marketplace. See the previous chapter for in-depth market research data.
To do predictions of the restaurant industrys long haul future, it?s crucial that you first analyze the current situation of the business. In reality, there is a need to study its operations and different problems because it progressed from Day 1 to the present. And this could only be performed through evaluating and upgrading the restaurants business strategy. This is not to be confused with the business plan you made when you were first starting up.
A company plan must certanly be updated frequently to ensure that you are meeting your goals and objectives. Having an usually updated business plan will help you chart your progress and make wise decisions regarding growth or some other element of your business.
To begin with, it is far better identify the different elements involved:
1. Company overview features
2. Company history
3. Analysis of marketing methods over time item, cost, position, campaign
4. Detailed assessment of competitors
5. Complete services and products and services provided and its development as to the is available at the moment
6. Income technique and estimates
7. Quality evaluation of management and operations
8. Study of financial plan, records of earnings and loses, and so on
9. The others
Change is constant, and to guarantee the long-term success of the restaurant industry, then changes in various aspects of society need to be considered existing circumstances and future estimates. These are believed to include the fluctuations in factors affecting the marketplace and in anything else that the business enterprise includes. Turn out to be a Concession Vendor ? Oblong Design Collective
LONDON (Reuters) - Nearly half of Britons expect their living standards to fall further by the time they vote in the next election in 2015, but the opposition Labour Party could still struggle to win if the economy does rebound, a pollster said on Monday.
A YouGov poll showed 46 percent of respondents thought they would be worse off in 2015 than now. Only seven percent saw a full recovery in the next two to three years.
YouGov president Peter Kellner said the level of pessimism was higher than usual, but said Labour's lead over the Conservatives, the senior ruling coalition partner, in other opinion polls of about eight or nine points could prove too small if the economy recovers.
"If the pessimism is confounded and the economy does show signs of steady growth between now and the next election, then the Conservative argument that the medicine is working, the economy has turned a corner and they are cleaning up Labour's mess would be quite a powerful message which Labour would have real difficulty counteracting," Kellner said.
"As long as Labour is blamed more than the Tories (Conservatives) for the mess that Britain is in, the Conservatives will have a fighting chance of winning the next election."
The questions in the poll about living standard expectations and how long it will take for the economy to recover were put to 1,761 respondents between February 27 and 28. It was conducted for The Resolution Foundation, a think tank
For more on the poll, click on: http://www.resolutionfoundation.org/publications/2015-living-standards-election/
(Reporting by William Schomberg Editing by Jeremy Gaunt.)
(This story was refiled to fix typo in paragraph 2)
MILAN (AP) ? Italian carmaker Fiat SpA reported a first-quarter loss of 83 million euros ($108 million) as European sales and profits at is U.S. partner Chrysler tumbled.
The loss posted Monday by the automaker, based in the northern Italian city of Turin, compares with a restated first-quarter profit of 35 million euros last year.
Revenues were down 2 percent to 19.75 billion euros, as performance in Latin America, Asia and its premium brands helped to compensate for declines in North America and Europe. Revenues were down 3 percent to 10 billion euros in North America and 4 percent to 4.4 billion euros in Europe.
Chrysler first-quarter profits dropped 65 percent as shipments of cars and trucks were down in preparation for new vehicle launches. Fiat's European operations lost 157 million euros.
Another simple but neat Evernote hack that came out of the 24-hour Disrupt NY Hackathon earlier today was Squirrel. Created by coder duo Zainab Ebrahimi and Jabari Bell, the hack turns articles Evernote readers have saved for reading later into a personalised newsletter. So, unlike the average email newsletter, Squirrel is populated with content the user actually wants to read.
Apr. 25, 2013 ? Most of us are familiar with the "winter blues," the depression-like symptoms known as "seasonal affective disorder," or SAD, that occurs when the shorter days of winter limit our exposure to natural light and make us more lethargic, irritable and anxious. But for rats it's just the opposite.
Biologists at UC San Diego have found that rats experience more anxiety and depression when the days grow longer. More importantly, they discovered that the rat's brain cells adopt a new chemical code when subjected to large changes in the day and night cycle, flipping a switch to allow an entirely different neurotransmitter to stimulate the same part of the brain.
Their surprising discovery, detailed in the April 26 issue of Science, demonstrates that the adult mammalian brain is much more malleable than was once thought by neurobiologists. Because rat brains are very similar to human brains, their finding also provides a greater insight into the behavioral changes in our brain linked to light reception. And it opens the door for new ways to treat brain disorders such as Parkinson's, caused by the death of dopamine-generating cells in the brain.
The neuroscientists discovered that rats exposed for one week to 19 hours of darkness and five hours of light every day had more nerve cells making dopamine, which made them less stressed and anxious when measured using standardized behavioral tests. Meanwhile, rats exposed for a week with the reverse -- 19 hours of light and five hours of darkness -- had more neurons synthesizing the neurotransmitter somatostatin, making them more stressed and anxious.
"We're diurnal and rats are nocturnal," said Nicholas Spitzer, a professor of biology at UC San Diego and director of the Kavli Institute for Brain and Mind. "So for a rat, it's the longer days that produce stress, while for us it's the longer nights that create stress."
Because rats explore and search for food at night, while humans evolved as creatures who hunt and forage during the daylight hours, such differences in brain chemistry and behavior make sense. Evolutionary changes presumably favored humans who were more active gatherers of food during the longer days of summer and saved their energy during the shorter days of winter.
"Light is what wakes us up and if we feel depressed we go for a walk outside," said Davide Dulcis, a research scientist in Spitzer's laboratory and the first author of the study. "When it's spring, I feel more motivation to do the things I like to do because the days are longer. But for the rat, it's just the opposite. Because rats are nocturnal, they're less stressed at night, which is good because that's when they can spend more time foraging or eating."
But how did our brains change when humans evolved millions of years ago from small nocturnal rodents to diurnal creatures to accommodate those behavioral changes?
"We think that somewhere in the brain there's been a change," said Spitzer. "Sometime in the evolution from rat to human there's been an evolutionary adjustment of circuitry to allow switching of neurotransmitters in the opposite direction in response to the same exposure to a balance of light and dark."
A study published earlier this month in the American Journal of Preventive Medicine found some correlation to the light-dark cycle in rats and stress in humans, at least when it comes to people searching on the internet for information in the winter versus the summer about mental illness. Using Google's search data from 2006 to 2010, a team of researchers led by John Ayers of San Diego State University found that mental health searches on Google were, in general, 14 percent higher in the winter in the United States and 11 percent higher in the Australian winter.
"Now that we know that day length can switch transmitters and change behavior, there may be a connection," said Spitzer.
In their rat experiments, the UC San Diego neuroscientists found that the switch in transmitter synthesis in the rat's brain cells from dopamine to somatostatin or back again was not due to the growth of new neurons, but to the ability of the same neurons there to produce different neurotransmitters.
Rats exposed to 19 hours of darkness every 24 hours during the week showed higher numbers of dopamine neurons within their brains and were more likely, the researchers found, to explore the open end of an elevated maze, a behavioral test showing they were less anxious. These rats were also more willing to swim, another laboratory test that showed they were less stressed.
"Because rats are nocturnal animals, they like to explore during the night and dopamine is a key part of our and their reward system," said Spitzer. "It's part of what allows them to be confident and reduce anxiety."
The researchers said they don't know precisely how this neurotransmitter switch works. Nor do they know what proportion of light and darkness or stress triggers this switch in brain chemistry. "Is it 50-50? Or 80 percent light versus dark and 20 percent stress? We don't know," added Spitzer. "If we just stressed the animal and didn't change their photoperiod, would that lead to changes in transmitter identity? We don't know, but those are all doable experiments."
But as they learn more about this trigger mechanism, they said one promising avenue for human application might be to use this neurotransmitter switch to deliver dopamine effectively to parts of the brain that no longer receive dopamine in Parkinson's patients.
"We could switch to a parallel pathway to put dopamine where it's needed with fewer side effects than pharmacological agents," said Dulcis.
The other researchers involved in the study, which was funded by grants from the Ellison Medical Foundation, were Pouya Jamshidi and Stefan Leutgeb of UC San Diego.
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The above story is reprinted from materials provided by University of California - San Diego.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
D. Dulcis, P. Jamshidi, S. Leutgeb, N. C. Spitzer. Neurotransmitter Switching in the Adult Brain Regulates Behavior. Science, 2013; 340 (6131): 449 DOI: 10.1126/science.1234152
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
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Public release date: 26-Jun-2013
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Another simple but neat Evernote hack that came out of the 24-hour Disrupt NY Hackathon earlier today was Squirrel. Created by coder duo Zainab Ebrahimi and Jabari Bell, the hack turns articles Evernote readers have saved for reading later into a personalised newsletter. So, unlike the average email newsletter, Squirrel is populated with content the user actually wants to read.